A SNPs Variation Map of LCORL Gene among Global Sheep Breeds Based on Wholegenome Resequencing

Abstract:

The LCORLgene is an important gene that influences the growth rate and body size of sheep.Constructing a comprehensive genetic variation map of this gene will help systematically assess its correlation with sheep growth traits and identify growth-related variation sites.However,no study has systematically screened the single nucleotide polymorphisms(SNPs) of this gene in different sheep breeds.In this study,based on whole-genome resequencing data from 1 615 sheep across 27 domestic and international breeds,4 777 high-confidence SNPs were identified,including 16 mutations in coding regions,with 10 missense mutations and 6 synonymous mutations.Additionally,this study found that one missense mutation(g.38075364G>A) is under selection in large-bodied Dorper sheep,suggesting that this site may be related to sheep growth traits.This study constructed a genetic variation map of the LCORL gene in sheep,providing valuable resources for exploring mutations and genetic markers related to sheep growth traits.