Abstract:The LCORL gene is an important gene that influences the growth rate and body size of sheep. Constructing a comprehensive genetic variation map of this gene will help systematically assess its correlation with sheep growth traits and identify growth-related variation sites. However, no study has systematically screened the single nucleotide polymorphisms (SNPs) of this gene in different sheep breeds. In this study, based on whole-genome resequencing data from 1,615 sheep across 27 domestic and international breeds, 4,777 high-confidence SNPs were identified, including 16 mutations in coding regions, with 10 missense mutations and 6 synonymous mutations. Additionally, this study found that one missense mutation (g.38075364G>A) is under selection in large-bodied Dorper sheep, suggesting that this site may be related to sheep growth traits. This study constructed a genetic variation map of the LCORL gene in sheep, providing valuable resources for exploring mutations and genetic markers related to sheep growth traits.
