Abstract:The "Silk Road" was the important land and sea channel for communication, trade and cultural exchanges between China and foreign countries in ancient times, and this is due to the domestication of silkworms by ancient Chinese people. Silkworm is an important economic insect, and the silk has high historical and cultural value and commercial value, which is of great significance to the study of silkworm. How to improve the quality and yield of silkworms and gain a leading position in the international silkworm research has become a key issue for China. In order to analyze the international research trend of silkworm in the 21st century, this paper is based on Web of Science core database and literature metrology strategy to carry out literature visualization research. In this paper, we search subject terms in WOS core database, and use VOSviewer, Excel2016 and other software to carry out visual analysis. It was found that with the development of modern biotechnology, the development of silkworm research in China also showed a good trend. And China should pay more attention to silkworm research, improve the breeding level, make comprehensive utilization of silkworm industry resources, and become the leader in silkworm research.