Abstract:Brucellosis is a zoonotic infectious disease, which not only endangers animal husbandry production and causes huge economic losses, but also seriously endangers human health. In this paper, the detection of Brucella sheep was first diagnosed by plate agglutination test and confirmed by test tube agglutination test. We collected 16167 sheep sera, 1229 were positive, and the positive rate was as high as 7.6%. This paper proposes comprehensive prevention and control measures to provide help for maintaining public health safety and ensuring people's health.