Abstract:The aim of this experiment was to investigate the toxicity effects of melittin-thanatin recombinant antimicrobial peptide (MT-W) on Kunming mice. The effects of MT-W on major organs of mice were studied by oral acute toxicity test and oral bioavailability test, and biochemical indexes such as alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in blood were detected, as well as the absorption of MT-W in vivo. The results showed that MT-W had no significant effects on the body weight and organ/body weight ratio of experimental mice, and there was no statistical difference in blood biochemical indexes between the control group and the control group. No MT-W was detected in plasma of mice given MT-W solution at 50mg/kg body weight. Studies have shown that MT-W has no obvious toxic and side effects on mice, and MT-W is not effectively absorbed after oral administration.
