Abstract:Obovine nodular skin disease also known as bovine nodular dermatitis, bovine nodular rash or bovine pimple skin disease. Clinically, it is characterized by fever, emaciation, skin edema, lymph node enlargement, local formation of hard nodules or ulcers, and is listed as a legally reported animal disease by the World Organization of Animal Health. The disease is acute and is a serious influence on the healthy development of cattle industry. Strengthening comprehensive prevention and control measures for biosafety and strengthening animal quarantine work can minimize the spread of the epidemic. The occurrence of cattle nodular skin disease, early diagnosis, early disposal, to control the spread of the epidemic vitally important. Local animal husbandry and veterinary departments should establish an internal epidemic notification system, implement the responsibility of epidemic reporting, so that relevant areas bordering the epidemic areas can establish immune quarantine areas as soon as possible to prevent the spread and spread of epidemic diseases.