Abstract:This article uses epidemiological investigation, clinical symptoms, pathological autopsy, laboratory differential diagnosis and other methods. We diagnosed and treated Tibetan sheep who died of unknown causes in 3 counties in the pastoral area of Qinghai. The results showed that the unknown death of Tibetan sheep in 3 counties of Qinghai was caused by chronic poisoning of Oxytropis chinensis. This uses Western medicine to strengthen the heart and replenish fluids, regulate the cerebral cortex, and relieve poisoning. The treatment plan of traditional Chinese medicine to calm the nerves, clear the heart and diuresis has effectively alleviated the disease of the flock.