Causes and Countermeasures of Low Antibody Titer after Tibetan Sheep Immunized with FootandMouth Disease Vaccine

Abstract:

The immune antibody titer after animal vaccination is an important index to evaluate the immune effect. This is the most important basis for measuring the stability of the herd immunity barrier in a region. This can effectively control the occurrence and prevalence of epidemic diseases by improving the titer of immune antibodies, and ensure the healthy development of animal husbandry. In recent years, in the evaluation of the effect of major animal compulsory immunization in our city, the antiantibody titer of Tibetan sheep FMD immunity is not high as a whole. From 2019 to 2021, 2,541, 2,786, and 2,980 sheep serum samples were tested by liquidphase blocking ELISA in veterinary laboratories, but the overall immune antibody pass rate of each batch of serum samples tested was between 55% and 75%. There is a certain gap between this and the requirement of higher authorities that the pass rate of immune antibodies should be kept above 70% all the year round. This paper analyzes the reasons for the low antibody titer of Tibetan sheep footandmouth disease vaccine and puts forward countermeasures. This aims to solve the problem of the overall low titer of immune antibodies in the prevention and control of footandmouth disease in Tibetan sheep in our city, establish an effective immune barrier, and ensure the highquality development of the sheep industry in our city.