Abstract:Plague is a Class A infectious disease mainly transmitted by Yersinia pestis through rat fleas. This is a natural foci disease that is widely prevalent among wild rodents, and the susceptible animals are mainly rodents. Once human beings are infected, there is great harm to their life and health. Although there is currently no epidemic of plague among animals in Yulin area. Inner Mongolia, Ningxia and other places bordering Yulin have reported the spread of plague among animals in recent years. This paper discusses the epidemic characteristics and transmission routes of plague, and studies and judges the current situation and risks faced by Yulin area. This further conducts indepth investigation and research on the prevention and control of local human plague, and provides a scientific basis for gradually establishing a systematic monitoring of plague among animals.