Abstract:Actinomycetes are anaerobic bacteria or microaerobic bacteria, which are a normal flora in the human body. It is often seen especially in the oral cavity. Infection may also occur after trauma or surgery. Chronic pyogenic granulomatous disease caused by actinomycetes. Lesions tend to occur in the face, neck, chest and abdomen, and are characterized by expanding to the surrounding tissues to form fistulas and discharging pus with sulfurlike particles. Highdose, longcourse penicillin treatment is effective for most cases, and tetracycline, erythromycin, lincomycin, and cephalosporin antibiotics can also be used. This also requires surgical drainage of pus and surgical excision of the fistula.