Abstract:In recent years, the prevention and control of animal diseases in China has achieved important results, the safety level of animalderived food has been significantly improved, and the level of public health security has been further improved. However, footandmouth disease still occurs and prevails in many regions of the world, seriously threatening the healthy development of modern animal husbandry. In order to effectively curb the occurrence and prevalence of the disease, immunization is the most effective, economical and key strategy to prevent and eliminate the disease. However, grassroots animal epidemic prevention workers occasionally have immune side effects when injecting cattle and sheep with footandmouth disease vaccines. This has caused certain economic losses to some farmers, and has also brought certain negative effects and resistance to the prevention and control of major animal diseases. This paper analyzes the causes, clinical symptoms, treatment and preventive measures of the immune side effects of the footandmouth disease vaccine in cattle and sheep. This provides a reference for grassroots frontline staff engaged in animal epidemic prevention.