1例育成期比格犬皮下肿瘤的组织病理染色分析

Histopathological Staining Analysis of a Subcutaneous Tumor in Beagle during Breeding Period

摘要:

犬皮肤肿瘤的发病常受到犬的品种和年龄影响,常见于老龄犬而鲜见于育成犬,尤其少见于育成期的比格犬。本文报告了1例育成期比格犬自发性肿瘤的病例,并对其进行组织采样、病理染色分析和鉴别。肿瘤组织苏木精-伊红染色检查发现,犬肿瘤组织位于真皮层,呈局灶性分布,内含大量嗜酸性胞质,细胞核形态异常。免疫组织化学结果表明,组织Vimentin和CK为阳性,而α-SMA、KI67、S-100和CD₃₄均为阴性。结合病理染色结果分析,初步判定可能是纤维组织细胞瘤。本次病例报告有望为今后的犬肿瘤疾病诊断提供依据,也为实验用比格犬的质量控制工作提供新的视角。

Abstract:

The incidence of skin tumors in canine is often influenced by breed and age.They are more common in elderly and rarely seen in growing dogs,especially in growing Beagles.This article reports a case of spontaneous tumor in a beagle during the growing period,and conducts tissue sampling,pathological staining analysis and identification.Hematoxylin-eosin staining of the tumor tissue revealed that the canine tumor was located in the dermis,distributed focally,and contained a large amount of eosinophilic cytoplasm with abnormal nuclear morphology.Immunohistochemical results showed that Vimentin and CK were positive,while α-SMA,KI67,S-100 and CD₃₄ were negative.Combined with the analysis of pathological staining results,the preliminary conclusion was probably fibrous histiocytoma.This case report provides a basis for the future diagnosis of canine tumor disease and new perspective for the quality control of beagle.