Abstract:With the development of molecular biotechnology,a new animal breeding methodmolecular breeding came into being in 2001.This technology makes up for the shortcomings of traditional breeding methods,and has the advantages of shortening generation interval and reducing breeding cost.As an important part of animal husbandry industry,sheep breeding faces urgent problem that urgent solution.Therefore,this paper reviewed the principles,algorithms and genotyping methods of genome selection,and summarized the application of genome selection technology in sheep breeding and the challenges faced during its application,aiming to provide theoretical reference for future research in sheep breeding.