疫苗剂量对家驼布病疫苗免疫抗体的影响

Effect of Vaccine Dosage on Immune Antibodies Against Camel Brucellosis Vaccine

摘要:

疫苗剂量对家驼布病免疫抗体消长有很大影响。选择多峰1岁家驼,注射不同剂量的A19布病疫苗,分别在不同时间段进行免疫抗体检测,评估疫苗剂量对免疫抗体的消长影响。结果显示:家驼注射1倍剂量和2倍剂量的A19布病疫苗,对免疫抗体的消长影响最小,且能最好的产生保护力。3倍剂量就会严重影响免疫抗体的消长。研究认为,家驼注射1倍剂量的A19布病疫苗,对布病疫苗免疫抗体的消长影响最小,是最适合家驼布病疫苗注射剂量。为优化家驼布病疫苗的免疫策略提供了科学依据。

Abstract:

The dose of vaccine has a great influence on the growth and decline of immune antibody of camelback disease.Different doses of brucellosis vaccine A19 were injected into one-year-old camel to detect the immune antibody at different time.The results showed that the injection of a 1x and 2x doses of brucellosis vaccine had the least influence on immune antibody and the best protective effect.Three times the dose can seriously affect the growth and decline of immune antibodies.The results showed that the dose of A19 brucellosis vaccine had the least influence on the immune antibody of brucellosis vaccine and was the most suitable dose for injection.The results provide scientific basis for optimizing the immunization strategy of hump disease vaccine.