猪繁殖与呼吸综合征的感染特性与防控分析

Infection Characteristics and Prevention of Porcine Reproductive and Respiratory Syndrome

摘要:

猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是影响全球猪业生产的病毒性疫病之一,我国又将其称“蓝耳病”。PRRS是由猪繁殖与呼吸综合征病毒(PRRS virus,PRRSV)感染引起的,在我国广泛流行,给养猪业造成严重经济损失。由于PRRSV能够引起猪只的免疫抑制,从而增加细菌性继发感染的几率,进而影响其它疫苗的免疫效果,此外,PRRSV抑制宿主免疫反应有利于PRRSV持续感染。当前商品化疫苗不能同时满足有效性和安全性,弱毒活疫苗的应用,进一步提高了PRRSV变异和重组的几率,使得PRRS成为世界上最具有挑战性的病毒性传染病之一。本文总结分析了PRRS防控难点,针对不同状况下猪群提出防控建议,以期为PRRS防控和净化提供思考。

Abstract:

Porcine reproductive and respiratory syndrome (PRRS) is one of the viral diseases affecting the global pig industry,and it is also called "blue ear disease" in China.PRRS is infected by porcine reproductive and respiratory syndrome virus (PRRSV),which is widespread in China and has caused serious economic losses to pig industry.PRRSV can cause immunosuppression in pigs,thereby increasing the probability of bacterial secondary infection,and thus affecting the immune effect of other vaccines.In addition,PRRSV inhibits the host immune response,which is conducive to the persistence of PRRSV infection.Current commercial vaccines cannot meet the requirements of both efficacy and safety,and the application of live attenuated vaccines further increases the probability of PRRSV mutation and recombination,making PRRS one of the most challenging viral infectious diseases in the world.This paper summarized and analyzed the difficulties of PRRS prevention and control,and put forward prevention and control suggestions for pigs under different conditions,in order to provide thoughts for PRRS prevention and control and purification.