Abstract:In order to evaluate the clinical diagnosis and differential diagnosis of malignant melanoma, two cases of malignant melanoma in dogs were diagnosed by histopathology and immunohistochemical staining. Histopathological examination showed cancer disorder, major fusiform cells and epithelioid two cell morphology, visible tumor giant cells, mitotic figures, tumor cells visible pigment granules in the cytoplasm, cell atypia, nucleoli larger, mitotic activity, belong to malignant melanoma typical histological features. Six kinds of tumor markers by immunohistochemistry showed CK (-), Vimentin (+), S-100 (+), CD34 (-), SMA-α (-), KI-67 (+). In conclusion, observation by histopathology and immunohistochemistry results can be diagnosed as malignant melanoma.
