Abstract:Weaning stress in calves refers to the process of transitioning from liquid breast milk to solid feed during weaning, which causes significant stress on the digestive system of calves. This stress reaction can affect the health and production performance of calves, which may lead to impaired growth and development, reduced feed intake, slow growth rate, dysfunction of the rumen, impaired immune function, and adverse reactions to the endocrine system of calves. Cows under weaning stress are also susceptible to other diseases, and their health level will be decreased. Relevant research shows that 17% of calves will show signs of respiratory diseases after entering the fattening environment, and reducing the occurrence of stress reaction in the early stage of calves can reduce the incidence rate of respiratory diseases in the fattening stage. Therefore, in the process of breeding, reasonable measures should be taken to alleviate the weaning stress of calves to improve their health level and production performance. This article aims to discuss the impact of weaning stress on the occurrence and spread of diseases in calves, and propose effective prevention and control strategies for this issue. By implementing these prevention and control strategies, the impact of weaning stress on calves can be effectively reduced, and the occurrence and spread of related diseases can be reduced.