Abstract:Contagious ovine pleuropneumonia, also known as mycoplasmal pneumonia, is a highly contagious infectious disease caused by mycoplasma. Its clinical features are high fever, cough, and serous and fibrinous inflammation of the chest and pleura. The disease mainly affects lambs aged 1 to 3 months. It often takes acute and chronic forms and has a high mortality rate. It is a common respiratory disease in sheep breeding. Antibiotics are mostly used for clinical treatment, but drug resistance often occurs, resulting in poor efficacy. In recent years, we have used early application of Chinese herbal medicine supplemented with more sensitive antibiotics for treatment, and achieved good therapeutic effects. This article observes the efficacy of four commonly used groups of traditional Chinese medicine prescriptions and selects a group of Chinese medicine prescriptions with the best efficacy, in order to provide solutions for clinical treatment.